Genetic Engineering and Diseases – Gene Drive & Malaria

  • Published: 21 September 2016
  • We have the choice to attack one of our oldest enemies with genetic engineering. But should we do it?

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    Lucien Delbert, Mike C, Ricardo Chavarria, Juha Wellman, Zachary Jordan, Patrick Chang, Adrian Mihali, Nicodemos Nicodemou, Lacey Larson, Austin Earnest, Andre Wee, Koroslak, Alex Brady, Roberto Cano, Andreas Stokholm, Plamen Ivanov, E Smith, Kieran Hunter-East, Christopher Trinh, Tony Kwok, Adam Rabenstein, Andrew Whitehurst, Alena Vlachova, Mackenzie Broadbent, Andreas Hertle, Martin Petersen, Kasturi Raghavan, Gregory Griffin, KiaTheDead, Aaron Stevens, Jimmy C, Benedikt Jaletzke, Jonathan Bowler, Zdravko Šašek, Wouter Stokhof, Zealotus, Long Vu, Fatman13, Jeremy Dumet, Miles Spoor, Mirton I, Al Fl, Jonathan Carter, Stanislaw Wasowicz, Marek Turcani, Francisco Santos, Justin Choi, Dagoberto Chapa, Chip Salzenberg, TinFung, Bob Bergeron, Peer, Justin Elstrott, Rachid Malik, Octavio Astillo, Romain Isnel, Rich Sekmistrz, Kuosora, Mozart Petter, Justin Jeffries, Nicola Licheri, Bahram Malaekeh, Florent Petterschmitt, David Mark, Gaby Germanos, Shweta Bharadwai, Lux Stamm, Marc Johann, Joe, Nefaur Khandker, Anders Madsen, Sarah Yoshi, monoxide, Brandon Meador, Dovydas Bartkevicius, Tyler Vigen, Michael Niella, Gordon Timilty, Slava Dzyba, Bagel Krippen Chandra, KodinCage, Miikka Harjuntausta, Magid Elgady, Vince Houmes, Irae Carvalho, Josh Talbot, Mr.Z, Pawel Urbanek, Russ Clarke, Lucas Tostes, Oscar Chamaria, Zachary Langdon, Steve Bollenbaugh, Xiaogiang Zheng, Peter LoPinto, Jenny Nordenborg, Evan Faas, Greg Fowler, Cicmil Mladen, Canut Durgun, Malovich, Cedric, Dave Anderson, Jones, Elliot, Denis Dube, David Allen, Dawson Reid, Jake Zwirdowski, Denis Leu


    Harvard FAQs on gene drive:

    Research paper on using CRISPR for malaria gene drive:

    Nature article on engineered mosquitos:

    STAT new article on using gene drive against Zika:

    Tech review article on using gene drive against malaria:

    Smithsonian on deadliness of mosquitos:

    Science article about the risks of the technology:

    New Yorker on Pros and Cons:

    Gates note on death rate through mosquitos:

    Status quo on field trial in the U.S.:

    Evolution working against gene drive technology:

    Research paper on evolution of resistance against gene drive:

    Science news on possible safety feature for gene drive:

    Help us caption & translate this video!

Comments • 18 743

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  • Alex Hashaga
    Alex Hashaga  8 hours back

    Pharma companies make billions off malaria medication. No way in hell they’d allow this to happen

    • Aslam Iqbal
      Aslam Iqbal  9 hours back

      Killing mosquito=saving humanity

      • ColeTrain316
        ColeTrain316  10 hours back

        Yes. Yes it is unethical to not use this technology. If it were primarily white children being affected, they already would have.

        • andrei simescu
          andrei simescu  12 hours back

          me: opens a window in summer
          mosquitos:ight imma hed in

          • andrei simescu
            andrei simescu  12 hours back

            Jesus its 2019 have we used this yet it's about time

            • Rhekkazu xaarlkyn
              Rhekkazu xaarlkyn  1 days back

              Who else saw the muto referance, that made me very happy

              Mutos are cool af

              • Bartosz Pietrzyk
                Bartosz Pietrzyk  1 days back

                DEW IT IT'S WORTH DA RISK

                • Ethereal Darkling
                  Ethereal Darkling  2 days back

                  It's a matter of when we conquer nature. If we are to truly progress, we have to. That also means conquering our own biological bodies which are subject to primeval instincts such as the obsession on carnality that is wreaking havoc what with overpopulation, unwanted kids, abortions, ruined relationships, wasted resources, environmental destruction and unfulfilled potential. Then gluttony- eating up the whole world with the insatiable appetite for meat and animal products. Then we have to enhance ourselves with mind uplifting and machine parts, or fully machine eventually, because these Zerg-like, squishy organic bodies are messy.

                  • Justin Mason
                    Justin Mason  2 days back

                    The choice has already been made long before to if we change the world around us or let it be, and the answer is to change it, always has been always will be. It I'd nature, just our nature for better and worse.

                    • brin brin
                      brin brin  3 days back

                      Mosquito : **exits**
                      Malaria : hey man i need a ride-

                      • Duce Okoroafor
                        Duce Okoroafor  3 days back


                        • ganerdene uurtsaih
                          ganerdene uurtsaih  3 days back

                          Adaption is unevietable we will be using crispr in the future.

                          • Stoney_Eagle
                            Stoney_Eagle  3 days back

                            I think it is a good thing IF there are no negative domino effects. But we will never know before we tried it. So it's a paradoxical question.

                            • killroy01 ToPai
                              killroy01 ToPai  4 days back

                              The choice is obvious, save lives and advance science.

                              • Victoria Petras
                                Victoria Petras  4 days back

                                Nah...too many humans

                                • Alok the legend gamer
                                  Alok the legend gamer  5 days back

                                  good stuff keep it up

                                  • ralfslapins
                                    ralfslapins  5 days back

                                    Im pretty sure latvia dosent have malaria
                                    But im not certain

                                    • Marqan
                                      Marqan  6 days back

                                      What if we just change those diseases so they kill the mosquitos?
                                      We're much better at destructive science than helpful one...

                                      • CallItKindle
                                        CallItKindle  6 days back

                                        This as far as I and many others in the comments can see seems to be a grand idea! However, more testing needs to be done and the final say should go down to those of us who are qualified and knowledgeable in the area; for instance this all sounds good and dandy but there could be repercussions we aren’t thinking about that could lead to a bigger problem. Scientists should be in full control of this and a democratic vote AMONG scientists should ensue before we bring it into political hands. We need to know if it’s safe after all. That being said the implications of this are still a little scary. Soon people will wonder what else we can genetically modify and soon enough we will live in a dystopia because enough people have edited themselves and doomed the world. We have to tread on thin ice at all times and be skeptical and reasonable. All intelligent life is doomed to destroy itself at one point or another, let’s leave this one to the scientists while the rest of us work on cutting down our wastes and providing a better living environment for all. As unfortunate as it sounds the environment is a cause much more for concern than editing genes of mosquitos

                                        • Ash
                                          Ash  7 days back

                                          mosquito: ITSE ME MALARIO

                                          • zack revolvex
                                            zack revolvex  1 weeks back

                                            no. naaaahh. dont do that.

                                            • Kalel Kijin
                                              Kalel Kijin  1 weeks back

                                              Lets just burn the while world, lets see if those Mosquitos survive

                                              • Anonimus 0000
                                                Anonimus 0000  1 weeks back

                                                My opinión is stop overpopulation

                                                • ParadoxTheLegend72 Leuterio

                                                  Dengue is deadly in the Philippines im aware of it.

                                                  • Zaid Khan
                                                    Zaid Khan  1 weeks back

                                                    Plz make a video about acid base plz plz plz plz plz😣😣😣😣😣

                                                    • Alison Lee
                                                      Alison Lee  1 weeks back

                                                      Bloodlust: unabated
                                                      Itchiness: unaffected
                                                      Cuteness: unharmed
                                                      Nuisance: same same
                                                      Buzz: still there
                                                      Malaria: *gone!*

                                                      I LOVE THE ANIMATION MORE THAN I ALREADY HAVE.

                                                      • Daccura
                                                        Daccura  1 weeks back

                                                        Basically Humans can play god by altering dna etc.

                                                        • HeadZgaming
                                                          HeadZgaming  1 weeks back

                                                          I might sound cruel to all those people, but playing god is NEVER good.

                                                          • CL Melonshark
                                                            CL Melonshark  5 days back

                                                            I'm not saying that we aren't destroying the ecosystem, we certainly are. But if we use what we created in the right way, we'll be able not "mess up, really, really bad"

                                                          • CL Melonshark
                                                            CL Melonshark  5 days back

                                                            @HeadZgaming And many organisms actually *depend* on us to survive, and I'm not talking about the agricultural animals and pets only. Cockroaches, city rats, pigeons, and other organisms would find it difficult to survive or even go extinct if we didn't alter our surroundings.

                                                          • CL Melonshark
                                                            CL Melonshark  5 days back

                                                            @HeadZgaming I mean, I wouldn't say mistakes aren't made in nature. But alright. And when have we stopped altering life? Think about the many foods you eat today, we bred their ancestors to our advantage. If we didn't we would have smaller, less tastier fruits, vegetables, even livestock if you think about it.

                                                          • HeadZgaming
                                                            HeadZgaming  5 days back

                                                            Im not saying that everything humanity does is wrong, but imo you dont start to play with life itself

                                                          • HeadZgaming
                                                            HeadZgaming  5 days back

                                                            Just look how perfectly balanced everything is, no mistakes are made in nature. Everything should be how it is. The only thing that humanity could add to that is destruction...

                                                        • Coppa Hydroxide
                                                          Coppa Hydroxide  2 weeks back

                                                          CRISPR will definitely be the way to stop malaria permanently

                                                          • Sike
                                                            Sike  2 weeks back

                                                            couldn‘t you just change the dna to kill all mosquitoes? (hopefully all other animals survive xD)

                                                            • Denis Pepic
                                                              Denis Pepic  2 weeks back

                                                              Fuck you guys and fuck this im going to Sibiria

                                                              • Kian Cabardo
                                                                Kian Cabardo  2 weeks back

                                                                My sister almost got bit by a musquito on her leg

                                                                • You'll never know lol
                                                                  You'll never know lol  2 weeks back

                                                                  I mean all these flying devil spawns arent going to effect us and animals if they were extinct

                                                                  • Redtooth 75
                                                                    Redtooth 75  6 days back

                                                                    Yes it will. Many animals and other insects feed on mosquitoes. If you kill them you would reduce the food supply for animals and insects that eat them.

                                                                • sum dragon
                                                                  sum dragon  2 weeks back

                                                                  i think we should do although anti vaxers would hate it but how cares about them anyways!

                                                                  • Kellam Yoshikage
                                                                    Kellam Yoshikage  2 weeks back

                                                                    Apparently this vid exploded earlier this year. Ended up doing a project on CRISPR 2 years back, but my understanding of the approach to this at the time was to create mosquitoes that couldn't breed. My particular project ended up focusing on trying to remove invasive species entirely by introducing mutations that makes males more attractive and infertile while females remained fertile with gene drive. It seemed relatively sound besides having to change legislation around capture to facilitate spreading it.

                                                                    One thing I stumbled on while doing research was that it's extremely problematic for a gene drive to fail; it behaves much like surviving an infection, and it becomes extremely difficult to spread the drive to that organism or even its offspring. On the other hand, changing multiple genes for the purpose of driving one trait (I think the term was multiplexing) lets the success rate go much higher, to the tune of a 13-14-fold version could reasonably spread through the entirety of Africa's mosquito population without failing.

                                                                    I should look this stuff up again, though.

                                                                    • Sanghamithran S
                                                                      Sanghamithran S  2 weeks back

                                                                      Is there any version control system like Git for CRISPER?

                                                                      • Mia Lipovšek
                                                                        Mia Lipovšek  2 weeks back

                                                                        We don't know what will happen and we can't know unless we try. If later our regrets are at a minimum, than good for us, and if not, at least we'll die trying. Isn't that better than letting another cople miliion people die just because we're afraid of taking a minor risk?

                                                                        • Mia Lipovšek
                                                                          Mia Lipovšek  2 weeks back

                                                                          Them: Is it really worth it to set loose genrtically modigied mosquitos? What are the consequences?
                                                                          Me: *Kill them all, no matter what it takes!!*

                                                                          • La Loquita :v De Centenilla

                                                                            Why is nobody talking about 5:52?
                                                                            OG fans know why...

                                                                            • Nekaku !
                                                                              Nekaku !  2 weeks back

                                                                              As someone who kills mosquitoes for a living for the last 5 years....Jesus man make it so they dont produce so many offspring please? Im dying out here in this heat!

                                                                              • Fakin Gaming
                                                                                Fakin Gaming  2 weeks back

                                                                                Without trying nobody can judge,, we may be successful!!!

                                                                                • HexaRecter
                                                                                  HexaRecter  2 weeks back

                                                                                  the public should not have anything to do with genes changes.
                                                                                  poeple are still affrayed of gmo if you forgot. (because it's not *NATURAL*)
                                                                                  only poeple how know what they are talking about should matter

                                                                                  • The Cutie Snowy Pls Give Cookies To My Kitty

                                                                                    Why r ppl doing memes bout this vid. THE CHILDREN ARE DYING!!! And so am i

                                                                                    • BLU Spy
                                                                                      BLU Spy  2 weeks back

                                                                                      the reason so many people die from malaria is because it spreads in third world shitholes that haven't invented their first wheel yet. If you erradicate malaria, the people who live their are probably gonna end up creating a new worse disease by just existing.

                                                                                      • Tobesticles Richardson
                                                                                        Tobesticles Richardson  2 weeks back

                                                                                        *hold X to edit*

                                                                                        • Đặp Chai Mẳn
                                                                                          Đặp Chai Mẳn  2 weeks back

                                                                                          🐍FUCKKKKKKKKKKKKKKKKKK 💣YOUUUUUUUUUUUUUUUUU💥

                                                                                          • epiclolyay
                                                                                            epiclolyay  2 weeks back

                                                                                            Could we also add a disease to the mosquitos which kills them off after breeding? That’d be great.